K. W. Leong

This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

The paper develops a microfluidic array to study immune cell interactions in a tumor microenvironment, showing that anti-PD-L1 treatment improves T cell infiltration and reduces cancer cell apoptosis.

This study uses blood vessel organoids from 22q11.2 DS patients to link genetic dysfunction to vascular malformations through single-cell transcriptomics and imaging.