S. Cai

Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

The paper shows WTAP undergoes phase transition during IFN-β stimulation to regulate m6A modification of ISG mRNAs and control their expression.

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

Mass mortality associated with Carpione Rhabdovirus in golden pompano (Trachinotus ovatus) in China: First report

This study reports the first natural infection of Carpione Rhabdovirus in golden pompano fish in China, associated with high mortality and characterized by viral morphology and genetic analysis.

A Role for Cross-linking Proteins in Actin Filament Network Organization and Force Generation

The paper investigates the role of actin filament crosslinking proteins in force generation during clathrin-mediated endocytosis in yeast, showing that increased crosslinking enhances internalization under high turgor pressure.

The molecular basis of pine wilt disease resistance in Pinus massoniana

This study identifies three molecular resistance strategies in Pinus massoniana cultivars against pine wood nematodes using transcriptome and metabolome profiling.

Human vascular organoids with a mosaic AKT1 mutation recapitulate Proteus syndrome

This paper creates a vascular organoid model with an AKT1 mutation to study Proteus syndrome and finds AKT inhibitors reverse vascular malformations.

Nanoscale analysis of human G1 and metaphase chromatin in situ

This study uses in situ electron cryotomography to analyze chromatin structure in G1 and metaphase human cells, revealing distinct nucleosome arrangements and absence of higher-order structures in certain states.

Bestrophin-4 relays Hes4 and interacts with Twist1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

This study identifies BEST4 as a tumor suppressor in colorectal cancer that interacts with Hes4 to inhibit EMT and metastasis.

Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-related Breast Cancer

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

Clonal evolution mediates Menin-inhibitor resistance in KMT2A-rearranged leukemias.

This study shows that Menin-inhibitor resistance in KMT2A-rearranged leukemias arises through clonal evolution, with resistance developing without prior exposure to the inhibitor.

Focused ultrasound-mediated brain genome editing

This paper demonstrates a method to edit the brain genome in mammals using focused ultrasound to temporarily open the blood-brain barrier for CRISPR/Cas9 delivery via intravenous injection.

Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

Membrane remodeling properties of the Parkinson's disease protein LRRK2

This study shows that LRRK2 binds and remodels lipid membranes, suggesting its role in membrane dynamics and signaling.

A Chitin-Binding Protein Ultra-highly expressed in the Outer Fold of Mantle is Related to Shell Colour in Pacific Oyster Crassostrea gigas

This study identifies a chitin-binding protein, CgCBP, highly expressed in the outer fold of the mantle of Pacific oyster Crassostrea gigas, which is linked to shell pigmentation through its role in periostracum structure.

Cavitation Induced Fracture of Intact Brain Tissue

This study measures fracture energy in intact brain tissue using needle-induced cavitation and hydraulic fracture models, finding values between 1.5 to 8.9 J/m2 depending on location and model.

In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts

The paper presents the first in situ evidence for a bridge-like structure of VPS13C at ER-lysosome contacts, supporting its role in lipid transport.

Meiotic budding yeast assemble bundled triple helices but not ladders

The paper uses cryo-ET to analyze budding yeast meiosis and finds meiotic triple helices (MTHs) instead of expected synaptonemal complexes.

Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

This study uses cryo-ET to show that most nucleosomes in yeast cells are non-canonical, challenging previous assumptions about their structure.

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

The paper shows that East Asian populations, particularly the Chinese Southern Han, have enhanced NK cell strength due to genetic admixture and natural selection of HLA class I alleles that interact with inhibitory KIR receptors.

TAZ inhibits GR and coordinates hepatic glucose homeostasis in normal physiologic states

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

Macromolecular and cytological changes in fission yeast G0 nuclei

The paper compares transcription, histone acetylation, and macromolecular packing in proliferating and quiescent G0 fission yeast nuclei using cytological and biochemical methods.

A collection of yeast cellular electron cryotomography data

The paper shares over 1,000 cryo-ET raw datasets of yeast cells to enable structural and 3-D biological insights.

Age-dependent characterization of the carotid and cerebral artery morphologies in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography

This study characterizes age-related morphological changes in carotid and cerebral arteries of sickle cell anemia mice using ultrasound and micro-CT, finding increased arterial dimensions and narrowing in SS mice.

High stretchability, strength and toughness of living cells enabled by hyperelastic vimentin network

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.

The in situ structures of mono-, di-, and tri-nucleosomes in human heterochromatin

This study uses cryo-ET to determine the in situ structures of mono-, di-, and tri-nucleosomes in human heterochromatin, revealing irregular paths and conformational variability.

Cryo-ET reveals nucleosome reorganization in condensed mitotic chromosomes in vivo

The paper uses cryo-ET to study nucleosome organization in fission yeast mitotic chromosomes, revealing cluster and megacomplex structures and explaining gene expression patterns during mitosis.

Natural Chromatin Is Heterogeneous And Self Associates In Vitro

This study investigates the structure of natural chromatin in vitro using cryo-ET, showing it forms compact masses with rare 30-nm fibers and is sensitive to divalent cations and histone modifications.