BiochemistrybioRxiv
Addressing the dNTP bottleneck restricting prime editing activity
K. Ponnienselvan, P. Liu, T. Nyalile…·S. A. Wolfe
This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.
DOI 10.1038/s41587-024-02405-x