Author

S. A. Wolfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

E. J. Sontheimer· 2 shared A. Desai· 1 shared A. Guilherme· 1 shared A. T. Joynt· 1 shared C. A. Schiffer· 1 shared C. P. Emerson· 1 shared D. Guo· 1 shared E. Tsagkaraki· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

E. J. Sontheimer

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Author profile →

2 papers

Recent·Most cited

Addressing the dNTP bottleneck restricting prime editing activity

K. Ponnienselvan, P. Liu, T. Nyalile, S. Oikemus, A. T. Joynt, K. Kelly, D. Guo, Z. Chen, J. M. Lee, C. A. Schiffer, C. P. Emerson, N. D. Lawson, J. K. Watts, E. J. Sontheimer, J. Luban, S. A. Wolfe

This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.

bioRxiv · Oct 21, 2023Biochemistry

CRISPR-enhanced human adipocyte 'browning' as cell therapy for metabolic disease

E. Tsagkaraki, S. Nicoloro, T. De Souza, J. Solivan-Rivera, A. Desai, Y. Shen, M. Kelly, A. Guilherme, F. Henriques, R. Ibraheim, N. Amrani, K. Luk, S. Maitland, R. H. Friedline, L. Tauer, , M. P. Czech

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

bioRxiv · Oct 13, 2020Bioengineering