PhysiologybioRxiv
Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel
Y. Wang, S. Olieslagers, A. B. Johnsen…·A. DSouza
The paper shows that the intrinsic heart rate has a circadian rhythm driven by a local clock in the sinus node, regulating Hcn4 expression and funny current.
DOI 10.1016/j.hrthm.2020.11.026