C. Cox

Systematic perturbation screens decode regulators of inflammatory macrophage states and identify a role for TNF mRNA m6A modification

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

Pathogenic Leptospira are widespread in the urban wildlife of southern California

The paper assesses Leptospira prevalence and risk factors in urban wildlife in southern California, finding widespread exposure in multiple species.

Twenty years of change in benthic communities across the Belizean Barrier Reef

The paper tracks 20-year changes in benthic communities along the Belizean Barrier Reef, showing declines in coral cover and increases in macroalgae, linked to climate and human factors.

Cyclodextrins increase membrane tension and are universal activators of mechanosensitive channels

This study shows cyclodextrins activate mechanosensitive channels by mimicking membrane tension through lipid removal, revealing a universal mechanism for channel activation.

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

Efficacy of Biofilm Disrupters Against Candida auris and Other Candida species

This study evaluates biofilm disrupters against Candida auris and other Candida species, finding they are more effective than chlorhexidine against certain isolates.

Piezo1 Induces Local Curvature in a Mammalian Membrane and Forms Specific Protein-Lipid Interactions

This study shows Piezo1 induces membrane curvature and forms specific lipid interactions, influencing both membrane morphology and lipid composition.

Circadian control of intrinsic heart rate via a sinus node clock and the pacemaker channel

The paper shows that the intrinsic heart rate has a circadian rhythm driven by a local clock in the sinus node, regulating Hcn4 expression and funny current.