T. Mishra

Accelerated Hematopoietic Stem Cell Aging in Space

This study shows spaceflight accelerates hematopoietic stem cell aging through molecular changes like reduced dormancy and mutagenesis, suggesting potential for prevention.

Immortalization and transformation of primary cells mediated by engineered ecDNAs

This paper describes a method to engineer large focal amplifications in primary cells using ecDNAs, showing they promote proliferation and transformation.

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation

This study models clonal evolution and oncogenic dependency in hematopoietic transformation using reversible mutagenesis and allelic frameworks.

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

B.1.617.3 SARS CoV-2 spike E156G/Δ157-158 mutations contribute to reduced neutralization sensitivity and increased infectivity

This study identifies spike mutations in B.1.617.3 SARS-CoV-2 variants that reduce neutralization sensitivity and increase infectivity.

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 mutated acute myeloid leukemia

This study identifies pDC-AML as a distinct AML subset with high RUNX1 mutations and pDC transcriptional features, suggesting CD123 targeting as a therapeutic strategy.

SARS CoV-2 nucleoprotein enhances the infectivity of lentiviral spike particles

This study identifies SARS CoV-2 nucleoprotein as an enhancer of spike-pseudotyped lentiviral particle infectivity without increasing sensitivity to RBD-based neutralization.

Cell-free DNA (cfDNA) and exosome profiling from a year-long humanspaceflight reveals circulating biomarkers

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.