H. Fu

Genetic variation in the species Arabidopsis thaliana reveals the existence of natural heat resilience factors for meiosis

This study identifies natural heat resilience factors in Arabidopsis thaliana that enhance meiotic stability under heat stress, with implications for crop breeding.

Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction

This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.

Pathological axonal enlargement in connection with amyloidosis, lysosome destabilization and hemorrhage is a major defect in Alzheimer's disease

This study identifies axonal enlargement linked to amyloidosis, lysosome destabilization, and hemorrhage as a key pathological feature in Alzheimer's disease.

Characterisation of cuticle mechanical properties: analysing stiffness in layered living systems to understand surface buckling patterns

The paper measures mechanical properties of plant cuticle layers during growth to understand how they influence surface buckling patterns in Hibiscus trionum flower petals.

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

Development of a qPCR assay and a LAMP assay for Verticillium longisporum detection and a triplex qPCR assay for simultaneous detection of V. longisporum, Leptosphaeria biglobosa and L. maculans from canola samples

Distinct SARS-CoV-2 populational immune backgrounds induce divergent RBD evolutionary preferences

The paper compares SARS-CoV-2 variants from China and other countries, finding that Chinese variants have more dispersed RBD mutations with higher ACE2 binding and less immune evasion potential due to a distinct immune background.

Effects of fructooligosaccharides and Saccharomyces boulardii on the compositional structure and metabolism of gut microbiota in students

This study examines how fructooligosaccharides and Saccharomyces boulardii affect gut microbiota structure and metabolism in students using an in vitro model, finding that their combination has unique benefits.

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

Mycobacterial DnaQ is an Alternative Proofreader Ensuring DNA Replication Fidelity

This study shows that mycobacterial DnaQ acts as an alternative proofreader, working with the PHP domain to maintain DNA replication fidelity and prevent mutations.

ATR inhibition augments the efficacy of lurbinectedin in small cell lung cancer

This study shows that combining ATR inhibition with lurbinectedin improves efficacy in SCLC, particularly in MYC-driven non-neuroendocrine tumors.

A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting SMAD4-SMAD3-DNA complex

This paper develops a multiplexed TR-FRET assay to screen small molecule inhibitors targeting the SMAD4-SMAD3-DNA complex, identifying gambogic acid and gambogenic acid as potential hits.

Aβ-aggregation-generated blue autofluorescence illuminates senile plaques, complex blood and vascular pathologies in the Alzheimer's disease

Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer

This study identifies the ALK2/BMP6 iron homeostasis pathway as a therapeutic target in LKB1-mutant lung cancer using live-cell imaging and transcriptome analysis.

Constitutively synergistic multiagent drug formulations targeting MERTK, FLT3, and BCL-2 for treatment of AML

The paper develops a nanoscale combination drug formulation targeting MERTK, FLT3, and BCL-2 to treat AML, showing improved synergistic responses in vitro and in patient samples.

Detection and differentiation of Xanthomonas translucens pathovars translucens and undulosa from wheat and barley by duplex quantitative PCR

This paper develops two duplex qPCR systems to specifically detect and differentiate Xanthomonas translucens pathovars translucens and undulosa in wheat and barley.

Underlying driving forces of the SARS-CoV-2 evolution: immune evasion and ACE2 binding affinity

This study analyzes SARS-CoV-2 mutations across all open-access genomes to determine their impact on immune evasion and ACE2 binding affinity, revealing distinct evolutionary patterns.

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

The paper shows that loss of HD-PTP, a tumor suppressor, promotes RAS-driven oncogenesis and is associated with adenosquamous lung cancer, suggesting it as a therapeutic target.

Calponin 2 harnesses metabolic reprogramming to determine kidney fibrosis

This study identifies Calponin 2's role in kidney fibrosis by linking cellular mechanics to metabolic reprogramming via fatty acid oxidation regulation.

ATM-Mediated Double-Strand Break Repair Is Required for Meiotic Genome Stability at High Temperature

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

Screening and Development of Constitutively Synergistic Combination Drug Formulations for T Cell Acute Lymphoblastic Leukemia

The paper identifies synergistic drug combinations for T-ALL using high-throughput screens and develops lipid nanoparticle formulations that maintain drug synergy and improve anti-leukemic activity.

Robust control of replication initiation in the absence of DnaA-ATP {leftrightharpoons} DnaA-ADP regulatory elements in Escherichia coli

The paper investigates the role of DnaA-ATP/ADP conversion in E. coli replication initiation, finding that intrinsic ATPase activity alone can maintain robust initiation, with regulatory elements enhancing stability during multifork replication.

Isolation and Transfection of Rice Egg Cells and Zygotes for Cellular Localization

This study isolates and transfects rice egg cells and zygotes to study cell cycle factors during embryogenesis.

A CDKB/KRP/FB3 cell cycle core complex functions in rice gametes and zygotes

This study identifies a core cell cycle complex in rice zygotes involving CDKB1, KRP4, KRP5, and FB3, showing their roles in regulating cell cycle progression and seed formation.

Two Competing Guilds as a Core Microbiome Signature for Health Recovery

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

Cavitation Induced Fracture of Intact Brain Tissue

This study measures fracture energy in intact brain tissue using needle-induced cavitation and hydraulic fracture models, finding values between 1.5 to 8.9 J/m2 depending on location and model.

Interfered Chromosome Pairing Promotes Meiosis Instability of Autotetraploid Arabidopsis by High Temperatures

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

Observation of reversal in twist-stretch coupling of RNA suggests a unified mechanism for the opposite couplings of DNA and RNA

This study observes that RNA's twist-stretch coupling reverses from positive to negative with multivalent cations, proposing a unified mechanism for DNA and RNA coupling based on deformation pathways.

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.