S. Dagar

Mild ER Stress Impedes Regulated Secretion By Governing Key Exocytotic and granulogenic Molecular Switches

The paper shows ER stress impairs DCV exocytosis in neuroendocrine cells by reducing key exocytotic and granulogenic switches via the CREB/ATF4/eIF2 axis.

Nonenzymatic template-directed replication using 2'-3' cyclic nucleotides under wet-dry cycles

This study demonstrates nonenzymatic template-directed RNA replication using 2'-3' cyclic nucleotides under wet-dry cycles at high temperature and alkaline conditions.

pH-responsive self-assembled compartments as tuneable model protocellular membrane systems

This study investigates pH-responsive self-assembly of amphiphiles to create model protocellular membranes with tunable properties.

Porphyrin in prebiotic catalysis: Ascertaining a route for the emergence of early metalloporphyrins

This study investigates how porphyrins influence metal ion-mediated prebiotic reactions, showing enhanced catalytic activity and substrate versatility in metal-porphyrin complexes.

Geochemical influences on nonenzymatic oligomerization of prebiotically relevant cyclic nucleotides

This study investigates nonenzymatic oligomerization of cyclic nucleotides under prebiotically relevant conditions, showing that DH-RH cycles and amphiphiles promote RNA-like oligomer formation.

Compositional heterogeneity confers selective advantage to protocellular membranes during the origins of cellular life

This study shows that compositional heterogeneity in protocellular membranes enhances their stability under multiple prebiotic selection pressures, making them more suitable for supporting early life.

Horizontal gene transfer as an indispensible driver for Neocallimastigomycota evolution into a distinct gut-dwelling fungal lineage

This paper identifies 283 horizontal gene transfer events in anaerobic gut fungi, showing HGT's role in their adaptation to the herbivorous gut environment.