Diverse routes of Club cell evolution in lung adenocarcinoma
Y. Chen, R. Toth, S. Chocarro, D. Weichenhan, J. Hey, P. Lutsik, S. Sawall, G. T. Stathopoulos, C. Plass, R. Sotillo
This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.
bioRxiv · Jun 10, 2021 · PreprintCancer Biology