Author

S. Sekulovski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

S. Trowitzsch· 2 shared A. Pitiriciu· 1 shared C. Schmidt· 1 shared E. P. Ramsay· 1 shared F. Baas· 1 shared J. Martinez· 1 shared K. Heitmeier· 1 shared L. S. Stelzl· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

S. Trowitzsch

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2 papers

Recent·Most cited

BiochemistrybioRxivSep 3, 2022

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

S. Sekulovski, L. Susac, L. S. Stelzl…·S. Trowitzsch

This study presents cryo-EM structures of human TSEN with pre-tRNAs, revealing substrate recognition mechanisms and structural basis of PCH-associated mutations.

DOI 10.1038/s41594-023-00992-y

humanstructural biology

𝕏 PostBluesky

BiochemistrybioRxivAug 3, 2020

Assembly defects of the human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

S. Sekulovski, P. Devant, S. Panizza…·S. Trowitzsch

This study shows that TSEN assembly defects in PCH patients impair pre-tRNA processing by reducing cleavage activity despite normal endonuclease activity.

DOI 10.1038/s41467-021-25870-3

humanstructural biology

𝕏 PostBluesky