NAIP-NLRC4 Inflammasome Activation in Tuft Cells Activates a PGD2-ILC3 Signaling Circuit that Protects Against Enteric Infection.
M. J. Churchill, R. Bauer, R. Honodel, T. Christopher, S. Smita, L. Warner, B. M. Mooney, E. D. T. Wojno, I. Rauch
This study shows that NAIP-NLRC4 inflammasome activation in tuft cells releases PGD2, which signals to ILC3s to enhance antibacterial defenses against Salmonella Typhimurium.
bioRxiv · May 11, 2023Immunology