M. Perretti

Placental inflammation leads to abnormal embryonic heart development

This study shows that placental inflammation caused by neutrophils leads to abnormal embryonic heart development and postnatal cardiac dysfunction, which can be mitigated by reducing placental inflammation.

Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease

This study identifies reduced Annexin A1 levels in dengue patients and mice, showing that AnxA1 agonists reduce disease severity by modulating mast cell degranulation.

The Immunomodulatory Effects of Social Isolation in Mice are Linked to Temperature Control

This study shows that social isolation in mice increases resistance to bacterial sepsis, linked to changes in gene expression and cytokine production, which can be reversed by artificial nesting.

The Atlas of Inflammation-Resolution (AIR)

The AIR Atlas provides a web-based resource for exploring inflammation and resolution processes, enabling bioinformatics analyses and systems biology approaches through integrated molecular interaction maps.

Extracellular vesicles from monocyte/platelet aggregates modulate human atherosclerotic plaque responses

This study shows that EVs from monocyte/platelet aggregates modulate atherosclerotic plaque responses, with Iloprost reducing their pro-inflammatory effects.

Immuno-moodulin: a new anxiogenic factor produced by autoimmune-prone T cells

The paper identifies Immuno-moodulin, a novel anxiogenic factor produced by autoimmune-prone T cells, and shows its role in modulating anxiety behavior in mice and its presence in patients with obsessive compulsive disorders.

Annexin A1 drives macrophage skewing towards a resolving phenotype to accelerate the regeneration of muscle injury through AMPK activation

This study identifies Annexin A1 as a driver of macrophage polarization towards a resolving phenotype via AMPK activation, enhancing muscle regeneration after injury.