Author

H. Machado

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

B. Palsson· 2 shared R. Szubin· 2 shared V. Nizet· 2 shared Y. Seif· 2 shared A. Anand· 1 shared A. M. Feist· 1 shared A. O. Bergland· 1 shared A. V. Sastry· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

B. Palsson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The lymphatic system favours survival of a unique T. brucei population, and its invasion results in major host pathology.

H. Machado, M. De Niz

This study uses intravital and ex vivo imaging to show T. brucei colonization of lymph nodes and the lymphatic system, revealing unique parasite behavior and host pathology.

bioRxiv · Apr 10, 2023 · PreprintMicrobiology

Adipocyte lipolysis protects the host against Trypanosoma brucei infection

H. Machado, P. Hofer, R. Zechner, L. M. Figueiredo

This study shows that adipocyte lipolysis during Trypanosoma brucei infection reduces parasite burden and fat mass, acting as a host-protective mechanism.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila

H. Machado, A. O. Bergland, R. Taylor, S. Tilk, E. Behrman, K. Dyer, D. Fabian, T. Flatt, J. Gonzalez, T. Karasov, I. Kozeretska, B. P. Lazzaro, T. Merritt, J. Pool, K. O'Brien, , D. Petrov

The paper identifies parallel seasonal allele frequency shifts in Drosophila melanogaster across North America and Europe, linking environmental conditions to genomic responses to selection.

bioRxiv · Feb 15, 2021 · PreprintEvolutionary Biology

Expression of Castanea crenata Allene Oxide Synthase in Arabidopsis Improves the Defense to Phytophthora cinnamomi

S. M. Serrazina, H. Machado, R. Costa, P. Duque, R. M. Malho

Heterologous expression of the Castanea crenata allene oxide synthase gene in Arabidopsis thaliana improves the defense response to the pathogen Phytophthora cinnamomi.

bioRxiv · Oct 9, 2020Plant Biology

Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses

S. Poudel, H. Tsunemoto, Y. Seif, A. V. Sastry, R. Szubin, S. Xu, H. Machado, C. Olson, A. Anand, J. Pogliano, V. Nizet, B. Palsson

This paper identifies 29 independently modulated gene sets in S. aureus using ICA, linking them to regulators and physiological responses.

Proceedings of the National Academy of Sciences · Jul 2, 2020Peer-reviewedMicrobiology

Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

H. Machado, Y. Seif, G. Sakoulas, C. A. Olson, R. Szubin, B. Palsson, V. Nizet, A. M. Feist

This study identifies media-specific mutational mechanisms of vancomycin resistance in S. aureus using adaptive laboratory evolution and sequencing.

bioRxiv · Jun 7, 2020Microbiology