Author

S. W. Cai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

T. de Lange· 2 shared T. Walz· 2 shared E. Nudler· 1 shared H. Takai· 1 shared J. C. Zinder· 1 shared M. Bush· 1 shared V. Svetlov· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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2 shared papersBiophysics

T. de Lange

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2 papers

Recent·Most cited

BiophysicsbioRxivMay 8, 2023

POT1 recruits and regulates CST-Polα/Primase at human telomeres

S. W. Cai, H. Takai, T. Walz, T. de Lange

This study determines the structure of human CST bound to POT1/TPP1, revealing how POT1 recruits and regulates CST-Polα/Primase at telomeres through phosphorylation-dependent interactions.

DOI 10.1016/j.cell.2024.05.002

humanstructural biology

𝕏 PostBluesky

BiochemistrybioRxivDec 17, 2021

Cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state

S. W. Cai, J. C. Zinder, V. Svetlov…·T. de Lange

The paper presents a cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state, revealing its architecture and informing on disease mutations.

DOI 10.1038/s41594-022-00766-y

humancryo-EM

𝕏 PostBluesky