Biphasic response of CD8 T cell to asparagine restriction maximizes its metabolic fitness and antitumoral functionality
J. R. Gnanaprakasam, L. Liu, X. Chen…·R. Wang
This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.