The Hyaluronan Synthase isoforms direct distinct patterns of fibroblast activation linked to fibrosis progression versus resolution following renal ischaemia
I. Grigorieva, A. Midgley, C. Brown, G. Chavez, A. Williams, D. Manetta-Jones, T. Bowen, D. Chan, A. Plaas, R. Chavez, R. Steadman, U. Khalid, S. Meran
This study compares HA and HAS enzyme expression in kidney development, health, disease, and recovery, identifying distinct roles of HAS1 and HAS2 in fibroblast activation linked to fibrosis progression versus resolution.
bioRxiv · Mar 27, 2024Pathology