D. Jia

Interplay of hierarchical dynamics and their microscopic structures of polyampholyte gels and proteins

The paper studies the hierarchical dynamics of polyampholyte gels using dynamic light scattering, identifying a new mode with a stretched exponential decay and linking it to segmental motion and charge balance.

A Lung Cancer Mouse Model Database

The paper establishes a database of lung cancer mouse models to improve data comparison and translational relevance by aligning mouse mutations with human lung cancer mutations.

Decoding the coupled decision-making of the epithelial-mesenchymal transition and metabolic reprogramming in cancer

This study investigates how metabolism and epithelial-mesenchymal transition (EMT) interact in cancer cells to enable metastasis through coupled decision-making networks.

Single-shot Volumetric Chemical Imaging by Mid- Infrared Photothermal Fourier Light Field Microscopy

This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.

Topologically frustrated dynamics in an uncharged Tetra-PEG gel

The paper investigates non-diffusive topologically frustrated dynamics in an uncharged gel matrix and finds a stretched exponential dynamics with exponent around 1/3.

Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung Cancers

This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.

Insulin Resistance Mediates Crosstalk between Skeletal Muscle and the Heart to Prevent Cardiac Dysfunction

This study shows that insulin resistance in skeletal muscle protects the heart from dysfunction in diet-induced obesity, despite worsening obesity and metabolic syndrome.

JNK-IN-8, a c-Jun N-terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke

This study shows JNK-IN-8 improves functional recovery in ischemic stroke by reducing neuroinflammation through the JNK/NF-κB pathway.

Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals

This study compares the nuclear export and cargo dissociation mechanisms of RanBP1 in fungi and animals, revealing distinct interactions and complex stoichiometry.

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

The paper identifies interconnected feedback loops among ESRP1, HAS2, and CD44 that regulate ZEB1 levels and drive epithelial-hybrid-mesenchymal transition in cancer, with ESRP1 as a key regulatory node.

Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma

This study identifies modularity in metabolic gene expression as a prognostic biomarker for hepatocellular carcinoma, correlating higher modularity with worse patient outcomes.

Distinguishing Mechanisms Underlying EMT Tristability

The paper uses experimental and theoretical approaches to evaluate two models of EMT dynamics, finding experimental evidence supporting the ternary chimera switch model over the cascading bistable switches model.