Cancer BiologybioRxiv
The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity
S. M. Ahmed, P. D. Ramani, S. Q. R. Wong…·P. Droge
This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.
DOI 10.1371/journal.pone.0215696