R. DasGupta

Elucidating microRNA-34a organisation within Human Argonaute-2 by DNP MAS NMR

The paper uses DNP MAS NMR to study the structural organization of miR-34a in hAgo2 and its interaction with SIRT1 mRNA, revealing conformational changes and dynamic states.

Enhanced NK cell proficiency in solid tumors through antigen-specific memory via NKG2C/A-HLA-E/ABC recruited to tumors by CXCR2

This study shows that antigen-specific memory NK cells can be generated in ovarian cancer, enhancing their cytotoxicity and tumor reactivity through NKG2C/A-HLA-E/ABC interactions and CXCR2-mediated migration.

Deciphering the function of intrinsic and genomics-driven epigenetic heterogeneity in head and neck cancer progression with single-nucleus CUT&RUN

This study develops a single-nucleus CUT&RUN assay to analyze histone modifications in HNSCC cell lines, revealing how epigenetic changes contribute to cancer progression and heterogeneity.

Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

The paper introduces OM2BFB, an algorithm detecting BFB amplifications using OGMs, showing high precision and recall, and finds BFB events are common in certain cancers but not linked to intratumoral heterogeneity or rapid genome change.

The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription

This study shows that HIV-1 capsid acts as a nanoscale container for reverse transcription, with NERT activity dependent on gp41 and not requiring IP6 or a mature capsid.

Fiberbots: Robotic fibers for high-precision minimally invasive surgery

This paper develops robotic fibers (fiberbots) that enable high-precision motion through thermal expansion, demonstrating scalability and integration with medical devices for potential applications in surgery and biomedical engineering.

Deciphering drug response and phenotypic heterogeneity of cancer cells using gene ensembles of regulatory units defined by chromatin domains

The paper analyzes the relationship between TAD activity and drug response in cancer cells and patients, finding stronger correlations with TADs than individual genes.

Data-driven inference of crosstalk in the tumor microenvironment

The paper develops a data-driven method to deconvolute bulk tumor transcriptomes and predict cancer-stromal crosstalk in 20 solid tumor types, revealing new insights into signaling patterns.

A Method to sort heterogenous cell populations based on migration in 2D and 3D environments

This paper introduces a method to sort migratory cancer and immune cells based on their spontaneous migration in 2D and 3D environments, revealing enhanced cytotoxicity in enriched migratory cytotoxic T lymphocytes.

Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

The paper develops a single-cell assay to analyze EphA receptor clustering in cancer cells, revealing its persistence through division and association with migration and drug resistance.

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

This paper identifies HMGA2 as a regulator of DNA supercoiling and replication fork stability, showing its protective role against DNA damage from topoisomerase poisons and its potential as a therapeutic marker in cancer.