T. Couffinhal

Increased endothelium activation and leakage do not promote diastolic dysfunction in mice fed with a high fat diet and treated with L-NAME

This study shows that endothelial activation and leakage do not contribute to diastolic dysfunction in HFD+L-NAME treated mice.

Cardiac pericytes are necessary for coronary vasculature integrity and cardiomyocyte differentiation

This study shows that cardiac pericyte depletion in adult mice causes coronary endothelial leakage, cardiomyocyte dedifferentiation, and systolic/diastolic dysfunction.

Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart

This study identifies a late postnatal developmental stage in rodents where cardiomyocyte surface crests mature, regulating diastolic function through ephrin-B1-dependent mechanisms.

Repression of Pdzrn3 is required for heart maturation and protects against heart failure

This study identifies Pdzrn3 as a regulator of cardiomyocyte polarization and maturation, showing its role in heart failure development and potential as a therapeutic target.

Mast cells participate in the development of diastolic dysfunction in diabetic obese mice

The paper investigates the role of mast cells in diastolic dysfunction in diabetic obese mice, finding that mast cell degranulation inhibition reduces end diastolic pressure and vascular leakage.