T. Eschenhagen

This study shows that 1 μM retinoic acid is necessary and sufficient to induce a fully human-like atrial phenotype in hiPSC-CMs, overcoming methodological challenges in RA concentration control.

This study shows that an ACTN2 mutation leads to proteopathy in human iPSC-derived cardiomyocytes through protein aggregation and activation of proteolytic systems.

This study shows that transplanting immature engineered heart tissue patches improves cardiomyocyte engraftment in a chronic injury guinea pig model.

This study shows transplanted cardiomyocytes actively contribute to heart function recovery after injury using optogenetic control in a guinea pig model.

This study shows that activating PPARD signaling enhances metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

This study transplants human engineered heart tissue (EHT) into chronically injured guinea pig hearts and finds limited functional improvement despite engraftment.

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

MUSCLEMOTION quantifies cardiac contraction in vitro and in vivo, providing reliable pharmacological and disease phenotype data across multiple models.