ImmunologybioRxiv
cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA
T. Schumann, S. C. Ramon, N. Schubert…·R. Behrendt
The paper shows that loss of SAMHD1 leads to chronic DNA damage and cGAS/STING-dependent type I interferon production in mice, linking it to autoimmunity and cancer.
DOI 10.1084/jem.20220829