Author

T. Guillard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

D. Skurnik· 3 shared A. Muggeo· 2 shared E. Frapy· 2 shared G. Pier· 2 shared S. Moussalih· 2 shared A. Babosan· 1 shared A. Bonnomet· 1 shared A. Kropec· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

D. Skurnik

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The panC-encoded pantothenate synthetase to tackle carbapenem-resistant OprD Pseudomonas aeruginosa mutant revealed through Tn-Seq

C. Van Maele, S. Caboche, M. Moutel, A. Bonnomet, S. Moussalih, E. Luczka, H. Jacquier, A. Muggeo, T. Guillard

This study identifies panC as a therapeutic target in OprD-deficient Pseudomonas aeruginosa by showing its role in growth and virulence through transposon sequencing and CRISPRi.

bioRxiv · Oct 19, 2023 · PreprintMicrobiology

Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: a new approach to prevent and treat bacterial infections

K. Johnson, J. Delaney, T. Guillard, F. Reffuveille, J. Varin-Simon, K. Li, A. Wollacott, E. Frapy, S. Mong, H. Tissire, K. Viswanathan, F. Touti, G. Babcock, Z. Shriver, B. Pentelute, , D. Skurnik

This paper develops an antibody-drug conjugate targeting Pseudomonas aeruginosa that kills bacteria with minimal mammalian cell toxicity and synergizes with antibiotics.

bioRxiv · Dec 28, 2022 · PreprintMicrobiology

A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates

S. Pons, E. Frapy, Y. Sereme, C. Gaultier, F. Lebreton, A. Kropec, O. Danilchanka, L. Schlemmer, C. Schrimpf, M. Allain, F. Angoulvant, H. Lecuyer, S. Bonacorsi, H. Aschard, H. Sokol, , D. Skurnik

This study uses TnSeq to identify E. coli K1 genes important for meningitis, focusing on PNAG as a vaccine target, showing its efficacy against E. coli and Group B Streptococcus in neonatal models.

bioRxiv · Dec 22, 2022Microbiology

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

A. Babosan, D. Skurnik, A. Muggeo, G. Pier, T. Jove, M.-C. Ploy, S. Griveau, F. Bedioui, S. Vergnolle, S. Moussalih, C. de Champs, D. Mazel, T. Guillard, Z. Baharoglu

The study shows that aminoglycosides can induce the SOS response in E. coli via a qnrD-plasmid, leading to qnrD transcription through NO accumulation driven by plasmid-encoded genes.

bioRxiv · Apr 29, 2021Microbiology