T. Sano

The MKK3 MAPK cascade integrates temperature and after-ripening signals to modulate seed germination

This study identifies the MKK3 MAPK cascade as a regulator of seed germination temperature range by integrating temperature and after-ripening signals through phytohormone metabolism.

Open-loop lab-on-a-chip technology enables remote computer science training in Latinx life sciences students

This paper demonstrates that lab-on-a-chip technology combined with internet-based project-based learning can effectively train Latinx students in computational biology and increase their interest in STEM careers.

Commensal-specific CD4 T cells promote inflammation in the central nervous system via molecular mimicry

This study shows that specific T cells recognizing commensal bacteria can cause CNS inflammation through molecular mimicry of host proteins.

The centromere/kinetochore is assembled through CENP-C oligomerization

This study shows that CENP-C oligomerization is essential for centromere function by organizing centromeric chromatin and maintaining kinetochore assembly in vertebrates.

Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion

The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

This study identifies redundant cytokine signals, particularly IL-6, IL-21, and IL-23, that drive Th17 cell differentiation in mesenteric lymph nodes induced by segmented filamentous bacteria.

Cardiovascular effects of intravenous colforsin in normal and acute respiratory acidosis canine models: a dose-response study

This study evaluates the cardiovascular effects of colforsin in normal and acute respiratory acidosis canine models, finding it increases cardiac output and reduces systemic vascular resistance compared to baseline.