ImmunologybioRxiv
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells
E. M. Kwesi-Maliepaard, M. A. Aslam, M. F. Alemdehy…·H. Jacobs
This study shows that DOT1L prevents premature differentiation of CD8+ T cells and maintains their epigenetic identity, independent of antigen exposure.