C. McLean

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

An untargeted metabolomics approach to characterize dissolved organic matter in groundwater of the Samail Ophiolite

This study uses untargeted metabolomics to analyze dissolved organic matter in serpentinizing groundwater, revealing correlations with fluid type and microbial communities, and identifying potential biosignatures.

Harmful Algal Bloom-Forming Organism Responds to Nutrient Stress Distinctly From Model Phytoplankton

This study examines how the harmful algal bloom-forming raphidophyte Heterosigma akashiwo shifts its metabolism under nitrogen and phosphorus stress, identifying distinct metabolic responses and potential biomarkers for bloom management.

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

This paper identifies a novel repair mechanism in cartilage where aggrecan-dependent sodium flux, triggered by mechanical injury, releases growth factors that promote tissue regeneration, which is impaired in osteoarthritis.

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

This study shows that YAP, a Hippo pathway protein, promotes melanoma cell invasion and metastasis, with specific target genes mediating these effects.

Carbon Assimilation Strategies in Ultrabasic Groundwater: Clues from the Integrated Study of a Serpentinization-Influenced Aquifer

The paper identifies carbon assimilation strategies in serpentinite-hosted microbial communities using metagenomics, metatranscriptomics, and metabolomics data from a subsurface aquifer.

The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells

This study shows that DOT1L prevents premature differentiation of CD8+ T cells and maintains their epigenetic identity, independent of antigen exposure.

Multiple Low Dose therapy: an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours

This paper shows that using multiple low doses of drugs targeting different components of a signaling pathway can effectively treat EGFR inhibitor-resistant NSCLC without resistance development.

Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1

The paper identifies an evolutionarily-conserved interaction between HDAC1 and DOT1L that influences H3K79 methylation and contributes to thymic lymphoma development.