SCARF1-induced efferocytosis plays an immunomodulatory role in humans, and autoantibodies targeting SCARF1 are produced in patients with systemic lupus erythematosus
A. M. Jorge, T. Lao, R. Kim, S. Licciardi, J. Elkhoury, A. D. Luster, T. K. Means, Z. G. Ramirez-Ortiz
This study shows SCARF1 is an apoptotic cell receptor on dendritic cells in humans, and autoantibodies against SCARF1 are linked to impaired efferocytosis in SLE patients.
bioRxiv · May 24, 2021Immunology