L. Gu

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

This study integrates single-cell and bulk RNA-seq data to identify ferroptosis-related genes in TNBC, developing a risk score model to predict prognosis and guide drug selection.

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

Rapid High-Throughput Isolation and purification of Chicken Myoblasts Based on Deterministic Lateral Displacement Microfluidic Chips

This study develops a microfluidic platform for isolating chicken myoblasts using deterministic lateral displacement, achieving 80% recovery and 99% purity.

CMTM6 maintains B cell intrinsic CD40 expression to regulate anti-tumor immunity

This study shows that CMTM6 in B cells maintains CD40 membrane levels by inhibiting its degradation, which is essential for B cell activation, anti-tumor immunity, and the effectiveness of CD40 agonists and ICB therapy.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Multifrequency control of Faraday wave bioassembly for constructing multiscale hPSC-derived neuronal networks

This paper introduces a multifrequency Faraday wave bioassembly technique to create multiscale neuronal networks from hPSCs, demonstrating spontaneous neuroelectrical activity.

Development of attenuated coxsackievirus B3 vectored intranasal pre-emptive pan-coronavirus vaccine

The paper designs an intranasal pan-coronavirus vaccine using epitopes from SARS-CoV-2 and zoonotic coronaviruses, showing immune responses in mice but needing further cross-reactivity testing.

Calcium Sulfate Microparticle Size Modification for Improved Alginate Hydrogel Fabrication and Its Application in 3D Cell Culture

The paper shows that ball-milled calcium sulfate microparticles improve alginate hydrogel fabrication by creating more stable suspensions, leading to homogeneous gels with consistent mechanical properties for 3D cell culture.

Picomolar-Level Sensing of Cannabidiol by Metal Nanoparticles Functionalized with Chemically Induced Dimerization Binders

This paper develops a method for detecting cannabidiol (CBD) at picomolar levels using gold nanoparticles functionalized with chemically induced dimerization binders, achieving high sensitivity and specificity in biological samples.

Small extracellular vesicles promote stiffness-mediated metastasis

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

Toward single cell tattoos: Biotransfer printing of lithographic gold nanopatterns on live cells

The paper introduces a biocompatible method to transfer gold nanopatterns onto live cells using biotransfer printing, showing high pattern fidelity and cell viability.

Concurrent measurement of O2 and isoprene production during photosynthesis: pros, cons, and metabolic implications

A leaf gas-exchange system measures net oxygen production and isoprene emissions during photosynthesis, revealing a linear correlation between net CO2 exchange and oxygen production with a consistent assimilatory quotient.

Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells

This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.

Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA polyubiquitination

Multi-omics of Circular RNAs and Their Responses to Hormones in Moso Bamboo (Phyllostachys edulis)

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

Recent selection is a major force driving cancer evolution

The paper investigates the evolutionary forces shaping cancer driver genes across primate phylogeny and modern human populations, finding recent selection pressures significantly influence their evolution.

Genome-wide H3K9 Acetylation Level Increases with Age-Dependent Senescence of Flag Leaf in Rice (Oryza sativa)

The paper investigates age-dependent H3K9 acetylation changes in rice flag leaf senescence, finding increased H3K9ac levels correlate with gene expression and identify regulatory networks.

Salidroside protects lipopolysaccharide-induced acute lung injury by regulating miR-145/ cytosolic phospholipase A2

This study shows that salidroside protects against LPS-induced acute lung injury by upregulating miR-145 and suppressing cPLA2 activity.

Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.

This study shows Klebsiella pneumoniae uses SARM1, a host protein, to suppress immune responses via type I IFN signaling, enhancing its survival in macrophages.

A high resolution single molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis

This paper introduces a new Arabidopsis transcriptome dataset with improved accuracy and resolution using novel Iso-seq analysis methods, enhancing transcript expression and splicing analysis.

5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes

This study identifies m5C mRNA modifications mediated by Plasmodium NSUN2 as critical for transcript stability and gametocyte development in malaria parasites.

Synthetic Nanobody-Functionalized Nanoparticles for Accelerated Development of Rapid, Accessible Detection of Viral Antigens

This paper introduces Nano2RED, a rapid, affordable diagnostic platform using nanobody-functionalized nanoparticles to detect viral antigens with high sensitivity and speed.

Deep Learning Identification of Stiffness Markers in Breast Cancer

This study uses deep learning to identify stiffness markers in breast cancer tissue, finding that straight collagen percentage best correlates with tissue stiffness.

Continuous cis-regulatory changes in an advantageous gene are linked with adaptive radiation in cichlid fishes

The paper identifies cis-regulatory changes in a gene linked to adaptive radiation in cichlid fishes by showing their impact on gene expression patterns across lineages.

Genomic bases underlying the adaptive radiation of core landbirds

The paper examines the genomic bases of ecological diversification in core landbirds, identifying adaptive enhancements in diet and vision related to their lifestyles.

CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

This study identifies METTL4 as the methyltransferase responsible for m6A methylation of U2 snRNA in Drosophila, confirming its enzymatic activity in vitro and in vivo.

Unique Proteomes Implicate Functional Specialization across Heterocysts, Akinetes, and Vegetative Cells in Anabaena cylindrica

The paper identifies unique proteomes in heterocysts, akinetes, and vegetative cells of Anabaena cylindrica, revealing functional specialization and proposing a model for their collaborative metabolic interactions.

Chidamide decreases c-MET mRNA methylation and in turn increases the sensitivity of non-small cell lung cancer to crizotinib

This study shows chidamide reduces c-MET mRNA methylation, increasing NSCLC sensitivity to crizotinib, particularly in cells with high c-MET expression.

Single-shot Mesoporous Silica Rods Scaffold for Induction of Humoral Responses Against Small Antigens

This study demonstrates that a single injection of mesoporous silica rods (MSRs) vaccine can generate potent and durable humoral immunity against small antigens like GnRH and Her2/neu peptides.

The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-dependent UMPylation

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.