Author

T. McHugh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:chromatin & epigenetic regulation· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

D. A. Kelly· 4 shared A. A. Jeyaprakash· 2 shared A. Gluszek-Kustusz· 2 shared J. Rappsilber· 2 shared J. Welburn· 2 shared J. Zou· 2 shared M. A. Abad· 2 shared A. Bird· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersCell Biology

D. A. Kelly

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

PLK1-Mediated Phosphorylation Cascade Activates the Mis18 Complex to Ensure Centromere Inheritance

P. Parashara, B. Medina-Pritchard, M. A. Abad, P. Sotelo-Parrilla, R. Thamkachy, D. Grundei, J. Zou, V. Das, Z. Yan, D. A. Kelly, T. McHugh, J. Rappsilber, A. A. Jeyaprakash

The paper identifies PLK1-mediated phosphorylation of Mis18 and Mis18BP1 as essential for activating the Mis18 complex to ensure CENP-A loading and centromere inheritance.

bioRxiv · Feb 23, 2024Cell Biology

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

R. Pantier, M. Brown, S. Han, K. Paton, S. Meek, T. Montavon, T. McHugh, D. A. Kelly, T. Hochepied, C. Libert, T. Jenuwein, T. Burdon, A. Bird

This paper shows MeCP2 binds methylated DNA without needing phase separation or heterochromatin, and its foci are rare in most mammals.

bioRxiv · May 9, 2023Cell Biology

Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis

A. Gluszek-Kustusz, B. Craske, T. Legal, T. McHugh, J. P. Welburn

This study identifies how phosphorylation regulates motor-PRC1 complexes to coordinate chromosome segregation and cytokinesis during mitosis.

bioRxiv · Mar 11, 2023Biochemistry

Centromere identity is dependent on nuclear spatial organization

W. Wu, T. McHugh, D. A. Kelly, A. L. Pidoux, R. C. Allshire

The paper shows that nuclear spatial organization, particularly near spindle-pole bodies, influences centromere identity by facilitating CENP-ACnp1 incorporation.

bioRxiv · Dec 16, 2021 · PreprintCell Biology

Molecular Basis for CPC-Sgo1 Interaction: Implications for Centromere Localisation and Function of the CPC

M. A. Abad, T. Gupta, M. A. Hadders, A. Meppelink, J. P. Wopken, E. Blackburn, J. Zou, L. Buzuk, D. A. Kelly, T. McHugh, J. Rappsilber, S. M. Lens, A. A. Jeyaprakash

This study identifies the molecular mechanism of CPC-Sgo1 interaction and shows its role in centromere localization and function through structural and functional analyses.

bioRxiv · Aug 27, 2021Cell Biology

Emergent properties of a mitotic Kif18b-MCAK-EB network

T. McHugh, J. Welburn

This study identifies a cooperative Kif18b-EB-MCAK network that enhances microtubule depolymerization during mitosis through integrated activities of its components.

bioRxiv · Aug 9, 2020 · PreprintBiochemistry

Microtubule end tethering of a processive Kinesin-8 motor Kif18b is required for spindle positioning

T. McHugh, A. Gluszek-Kustusz, J. Welburn

This study shows that Kif18b, a Kinesin-8 motor, regulates microtubule length and spindle positioning by tethering to microtubule ends through a phosphorylation-regulated mechanism.

bioRxiv · Mar 22, 2018Cell Biology

Single molecule mechanics reveal Kif15 as an active molecular ratchet with acute strain sensitivity

T. McHugh, H. Drechsler, A. D. McAinsh, N. J. Carter, R. A. Cross

This study investigates the single molecule mechanics of Kif15, revealing its strain sensitivity and directional load-dependent behavior.

bioRxiv · May 25, 2017Cell Biology