T. Melia

A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope

This study quantifies the timeline of nuclear autophagy in yeast, revealing a role for Dnm1 in nuclear envelope remodeling during cargo removal.

Spartin-mediated lipid transfer facilitates lipid droplet turnover

This study identifies spartin as a lipid transfer protein essential for lipid droplet turnover via lipophagy, revealing a new lipid transport module in its senescence domain.

ATG2A-mediated bridge-like lipid transport regulates lipid droplet accumulation

This study shows ATG2A uses bridge-like lipid transport to regulate lipid droplet accumulation by efficiently moving phospholipids between membranes.

The tissue-specific autophagic response to nutrient deprivation

This study examines how liver and brain cells use autophagy under normal and nutrient-deprived conditions, revealing tissue-specific differences in organelle turnover and cargo capture.

Mitoguardin-2 is a lipid transporter and its lipid transfer ability is required for function

This study identifies mitoguardin-2 as a lipid transporter that facilitates lipid transfer between mitochondria and lipid droplets, essential for mitochondrial and lipid droplet function.

Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome

This study identifies Atg39 as a cargo adaptor that targets inner nuclear membrane components for autophagy by forming lumenal vesicles in the nuclear envelope.