Author

T. Sigdel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1

Frequent Co-Authors

M. M. Sarwal· 3 shared I. Damm· 2 shared M. Kerwin· 2 shared P. Rashmi· 2 shared A. A. Silva· 1 shared A. L. F. Gouvea· 1 shared A. Rahman· 1 shared A. Sette· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

M. M. Sarwal

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Author profile →

4 papers

Recent·Most cited

Genetic deletion and pharmacologic inhibition of FcER1 reduces renal injury in mouse models of diabetic nephropathy.

P. Rashmi, A. A. Silva, T. Sigdel, I. Damm, A. L. F. Gouvea, S. Koliwad, V. Walavalkar, S. Hakroush, M. M. Sarwal

This study shows that reducing FcER1 signaling in mouse models of diabetic nephropathy decreases proteinuria and kidney damage.

bioRxiv · Sep 10, 2022 · PreprintImmunology

Plasma Proteome Perturbation for CMV DNAemia in Kidney Transplantation

T. Sigdel, P. Boada, M. Kerwin, P. Rashmi, D. Gjertson, M. Rossetti, S. Sur, D. Munar, J. Cimino, R. Ahn, H. Pickering, S. Sen, R. Parmar, B. Fatou, H. Steen, , CMV Systems Immunobiology Group

The paper identifies plasma proteomic changes associated with CMV DNAemia in kidney transplant recipients, revealing biomarkers for disease prediction and immune pathway insights.

bioRxiv · Aug 25, 2022 · PreprintImmunology

Perturbations of the T-cell immune repertoire in kidney transplant rejection

T. Sigdel, P. A. Fields, J. Liberto, I. Damm, M. Kerwin, J. Hood, P. Towfighi, M. Sirota, H. Robins, M. M. Sarwal

This study examines T-cell repertoire changes in kidney transplant recipients to understand rejection mechanisms, finding lower pre-transplant T-cell fractions and higher TCR turnover during acute rejection.

bioRxiv · Aug 24, 2022Immunology

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer

B. H. Lee, G. Kelly, S. Bradford, M. Davila, X. V. Guo, E.-a. D. Amir, E. M. Thrash, M. Solga, J. Lannigan, B. Sellers, J. Candia, J. Tsang, R. Montgomery, S. Tamaki, T. Sigdel, , A. Rahman

The paper describes a modified Helios mass cytometer protocol that improves data quality and reduces inter-instrument variability in multi-center studies.

bioRxiv · Apr 5, 2019Immunology