T. Strive

Hepatobiliary organoids derived from leporids support the replication of hepatotropic lagoviruses

This study demonstrates that hepatobiliary organoids from leporids support replication of hepatotropic lagoviruses, with species-specific tropism observed in different host organoids.

Pathogen profiling of Australian rabbits by metatranscriptomic sequencing

This study uses metatranscriptomic sequencing to profile pathogens in Australian rabbit liver samples, identifying known pathogens and highlighting the need for improved biosecurity practices.

Age and infectious dose significantly affect disease progression after RHDV2 infection in naive domestic rabbits

This study investigates the virulence of RHDV2 in rabbits, finding 100% case fatality rate regardless of age or dose, with disease symptoms appearing late in infection.

Frequent intergenotypic recombination between the non-structural and structural genes is a major driver of epidemiological fitness in caliciviruses

This study identifies frequent recombination between non-structural and structural genes in lagoviruses as a key driver of epidemiological fitness, leading to the emergence of multiple recombinant variants that outcompete parental strains.

First description of Hepatitis E virus in Australian rabbits

The paper reports the first detection of Hepatitis E virus in Australian rabbits through metatranscriptomic sequencing of liver samples.

Isolation, culture and maintenance of rabbit intestinal organoids, and organoid-derived cell monolayers

This paper establishes a protocol for isolating and maintaining rabbit intestinal organoids and monolayers, demonstrating their ability to mimic intestinal epithelium and support pathogen research.

Uncovering the microbiome of invasive sympatric European brown hares and European rabbits in Australia

This study compares the faecal microbiomes of invasive European brown hares and European rabbits in Australia, finding significant differences in microbial composition between the species.

Limited overlap in RNA virome composition among rabbits and their ectoparasites reveals barriers to virus transmission

The paper compares virome composition between rabbits and their ectoparasites, finding limited overlap and suggesting barriers to virus transmission.

Carrion flies as sentinels for monitoring rabbit calicivirus activity in Australia

This study uses carrion flies to monitor rabbit calicivirus activity in Australia, finding good correlation with rabbit samples and proposing a less biased surveillance method.

The discovery of three new hare lagoviruses reveals unexplored viral diversity in this genus

The paper discovers three new hare lagoviruses in Australian hares, highlighting unexplored viral diversity and suggesting extensive unsampled diversity in the genus.

Punctuated evolution of myxoma virus: rapid and disjunct evolution of a recent viral lineage in Australia

This paper shows that Myxoma virus in Australia experienced a sudden evolutionary change with a faster mutation rate and disrupted clock-like evolution between 1996 and 2012, likely due to environmental changes affecting rabbit populations.

A strain-specific multiplex RT-PCR for Australian rabbit haemorrhagic disease viruses uncovers a new recombinant virus variant in rabbits and hares

The paper develops strain-specific RT-PCR assays to detect lagoviruses in Australia and identifies a novel recombinant virus variant combining genes from GI.1a-Aus and GI.2.