M. Piper

Integrated omics analysis unveils a DNA damage response to neurogenic injury

The paper uses multi-omics analysis to study molecular changes in the bladder after spinal cord injury in rats and identifies DNA damage response pathways modulated by inosine treatment.

Sex-specific transgenerational effects of diet on offspring life history and physiology

This study shows that diet in parents affects grandoffspring lifespan and physiology, with sex-specific outcomes and benefits from dietary mismatch.

Targeting OLIG2 increases therapeutic responses in SHH medulloblastoma mouse models and patient-derived medulloblastoma organoids

This study shows that targeting OLIG2 with CT-179 reduces recurrence in SHH medulloblastoma models and improves survival when combined with radiotherapy.

Maternal and paternal sugar consumption interact to modify offspring life history and physiology

This study shows that maternal and paternal sugar consumption interact to influence offspring life history traits in fruit flies, with non-additive effects on lifespan and fecundity.

Drosophila melanogaster females prioritise dietary sterols for producing high quality eggs

This study shows that Drosophila melanogaster females can maintain high-quality egg production even when deprived of dietary cholesterol, suggesting that sterol prioritization for eggs does not reduce lifespan.

Age and infectious dose significantly affect disease progression after RHDV2 infection in naive domestic rabbits

This study investigates the virulence of RHDV2 in rabbits, finding 100% case fatality rate regardless of age or dose, with disease symptoms appearing late in infection.

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis

This study shows that Cep55 regulates PI3K/Akt signaling, essential for neocortical development and ciliogenesis, using mouse models and human organoids.

Conserved epigenetic regulatory logic infers genes governing cell identity

This study introduces a computational method to identify genetic regulators of cell identity using epigenetic data across diverse species and validates findings with CRISPR experiments.

Amino acid quality modifies the quantitative availability of protein for reproduction in Drosophila melanogaster

This study shows that amino acid quality affects protein availability for reproduction in Drosophila melanogaster, altering how protein quantity impacts reproductive output across different diets.

A strain-specific multiplex RT-PCR for Australian rabbit haemorrhagic disease viruses uncovers a new recombinant virus variant in rabbits and hares

The paper develops strain-specific RT-PCR assays to detect lagoviruses in Australia and identifies a novel recombinant virus variant combining genes from GI.1a-Aus and GI.2.