Author

T. Sych

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Organism:human· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

E. Sezgin· 5 shared B. Plochberger· 2 shared F. Weber· 2 shared H. Stangl· 2 shared A. Brandel· 1 shared A. Gorgens· 1 shared A. K. Menon· 1 shared A. Sherif· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersBiophysics

E. Sezgin

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Author profile →

6 papers

Recent·Most cited

Imaging single particle profiler to study nanoscale bioparticles using conventional confocal microscopy

T. Sych, A. Gorgens, L. Steiner, G. Gucluer, Y. Huge, F. Alamdari, M. Johansson, F. Aljabery, A. Sherif, S. Gabrielsson, S. E. Andaloussi, E. Sezgin

The paper introduces iSPP, an imaging-based method for analyzing nanoscale bioparticles using conventional confocal microscopy and provides software for its application.

bioRxiv · Jun 18, 2024Biophysics

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors

I. Menon, T. Sych, Y. Son, T. Morizumi, J. Lee, O. P. Ernst, G. Khelashvili, E. Sezgin, J. Levitz, A. K. Menon

The paper shows cholesterol inhibits GPCR-mediated phospholipid scrambling in synthetic vesicles, suggesting a mechanism for maintaining plasma membrane asymmetry.

bioRxiv · Nov 24, 2023Biochemistry

Single particle profiler for measuring content and properties of nano-sized bioparticles

T. Sych, J. Schlegel, H. Barriga, M. Ojansivu, L. Hanke, F. Weber, B. Bostancioglu, K. Ezzat, H. Stangl, B. Plochberger, J. Laurencikiene, S. El Andaloussi, D. Furth, M. Stevens, E. Sezgin

The paper introduces a high-throughput method called single particle profiler (SPP) to analyze content and biophysical properties of nanoscale bioparticles, demonstrating its application on mRNA encapsulation, viral binding, and biophysical heterogeneity.

bioRxiv · Jul 8, 2022Biophysics

The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains

T. Sych, R. Omidvar, R. Ostmann, T. Schubert, A. Brandel, L. Richert, Y. Mely, J. Madl, W. Roemer

This study investigates how the bacterial lectin LecA from P. aeruginosa alters membrane nanodomain organization by dispersing ordered domains using supported lipid bilayers.

bioRxiv · Apr 17, 2022Biophysics

Influence of the extracellular domains on the dynamic behavior of membrane proteins

C. O. Gurdap, L. Wedemann, T. Sych, E. Sezgin

This study investigates how extracellular domain properties affect membrane protein dynamics in lipid bilayers by analyzing sorting and mobility in model systems.

bioRxiv · Nov 15, 2021Biophysics

Lipoprotein particles interact with membranes and transfer their cargo without receptors

B. Plochberger, T. Sych, F. Weber, J. Novacek, M. Axmann, H. Stangl, E. Sezgin

This study shows lipoprotein particles transfer cargo to membranes without receptors, using cryo-EM and spectroscopy, revealing receptor-independent mechanisms.

bioRxiv · Aug 27, 2020Biophysics