Author

L. Hanke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:rat· 2

Frequent Co-Authors

B. Murrell· 6 shared G. M. McInerney· 6 shared D. J. Sheward· 5 shared C. Kim· 4 shared J. M. Coquet· 4 shared L. Perez Vidakovics· 4 shared A. Pankow· 3 shared E. Urgard· 3 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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6 shared papersImmunology

B. Murrell

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Single particle profiler for measuring content and properties of nano-sized bioparticles

T. Sych, J. Schlegel, H. Barriga, M. Ojansivu, L. Hanke, F. Weber, B. Bostancioglu, K. Ezzat, H. Stangl, B. Plochberger, J. Laurencikiene, S. El Andaloussi, D. Furth, M. Stevens, E. Sezgin

The paper introduces a high-throughput method called single particle profiler (SPP) to analyze content and biophysical properties of nanoscale bioparticles, demonstrating its application on mRNA encapsulation, viral binding, and biophysical heterogeneity.

bioRxiv · Jul 8, 2022Biophysics

Structural basis of Omicron neutralization by affinity-matured public antibodies

D. J. Sheward, P. Pushparaj, H. Das, C. Kim, S. Kim, L. Hanke, R. Dyrdak, G. M. McInerney, J. Albert, B. Murrell, G. B. Karlsson Hedestam, B. M. Hällberg

The paper identifies affinity-matured antibodies that neutralize SARS-CoV-2 Omicron with high potency and resolves their structure to explain cross-neutralization.

bioRxiv · Jan 3, 2022 · PreprintImmunology

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralising SARS-CoV-2 nanobodies

L. Hanke, D. J. Sheward, A. Pankow, L. Perez Vidakovics, V. Karl, C. Kim, E. Urgard, N. L. Smith, J. Astorga-Wells, S. Ekström, J. M. Coquet, G. M. McInerney, B. Murrell

This study identifies potent cross-neutralizing SARS-CoV-2 nanobodies from an alpaca immune repertoire using phage display and epitope mapping.

bioRxiv · Jul 25, 2021Immunology

Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost

D. J. Sheward, M. Mandolesi, E. Urgard, C. Kim, L. Hanke, L. Perez Vidakovics, A. Pankow, N. L. Smith, X. Castro Dopico, G. M. McInerney, J. M. Coquet, G. Karlsson Hedestam, B. Murrell

A single dose of a VOC-derived RBD protein boost enhances potent neutralizing antibodies against both Wu-Hu-1 and the VOC in previously vaccinated rhesus macaques.

bioRxiv · Apr 3, 2021 · PreprintImmunology

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

L. Hanke, H. Das, D. Sheward, L. Perez Vidakovics, E. Urgard, A. Moliner Morro, K. Changil, V. Karl, A. Pankow, N. Smith, B. Porebski, O. Fernandez-Capetillo, E. Sezgin, G. Pedersen, J. M. Coquet, , G. M. McInerney

A bispecific nanobody neutralizes SARS-CoV-2 and its variant B.1.351 by inducing spike trimer-dimers that prevent ACE2 binding.

bioRxiv · Mar 20, 2021Immunology

Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH

T. Schulte, M. D. Panas, L. Wiliams, N. Kedersha, J. S. Fleck, T. J. C. Tan, A. Olsson, A. M. Morro, L. Hanke, J. Nilvebrant, K. A. Giang, P.-A. Nygren, P. Anderson, A. Achour, G. M. McInerney

This study shows that Caprin-1 binds to G3BP1's NTF2 domain with pH sensitivity, regulating stress granule formation through a SLiM-mediated mechanism.

bioRxiv · Feb 5, 2021Biochemistry

SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses

M. Mandolesi, D. J. Sheward, L. Hanke, J. Ma, P. Pushparaj, L. Perez Vidakovics, C. Kim, K. Lore, X. Castro Dopico, J. M. Coquet, G. McInerney, G. B. Karlsson Hedestam, B. Murrell

This study shows that SARS-CoV-2 spike protein subunit vaccines induce strong neutralizing antibodies in mice and macaques, with high titers after a single dose or dose-sparing regimen.

bioRxiv · Jul 31, 2020Immunology

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

T. F. Custodio, H. Das, D. J. Sheward, L. Hanke, S. Pazicky, J. Pieprzyk, M. Sorgenfrei, M. Schroer, A. Gruzinov, C. Jeffries, M. Graewert, D. I. Svergun, N. Dobrev, K. Remans, M. Seeger, , C. Löw

This study isolates and characterizes synthetic nanobodies that neutralize SARS-CoV-2, identifying Sb23 with high affinity and neutralization activity.

bioRxiv · Jun 23, 2020Biophysics