T. Schubert

KIRA6 is an effective and versatile mast cell inhibitor of IgE-mediated activation

This study identifies KIRA6 as a dual inhibitor of LYN and FYN that suppresses IgE-mediated mast cell activation and inflammation.

Enhanced cardiac mitochondrial biogenesis by nitro-oleic acid remedies diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction

NO2-OA treatment improves diastolic dysfunction in HFpEF mice by enhancing mitochondrial biogenesis and oxidative phosphorylation.

Impact of single mutations on binding kinetics oftriplex forming oligos revealed by fluorescence proximitysensing in heliX(R) biosensor

The paper uses the heliX biosensor to measure binding kinetics of triplex forming oligos, revealing how single mutations affect dissociation constants and binding rates.

The bacterial lectin LecA from P. aeruginosa alters membrane organization by dispersing ordered domains

This study investigates how the bacterial lectin LecA from P. aeruginosa alters membrane nanodomain organization by dispersing ordered domains using supported lipid bilayers.

Connecting the Dots: PHF13 and cohesin promote polymer-polymer phase separation of chromatin into chromosomes

This study shows PHF13 and cohesin work together to drive chromatin compaction into chromosomes through polymer-polymer phase separation.

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

This paper evaluates GNS561, a PPT1 inhibitor, showing its efficacy against HCC by modulating lysosomal functions and inducing cell death in vitro and in vivo.