Author

T. Tsui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Florian· 1 shared B. C. Grieb· 1 shared B. N. Smith· 1 shared C. Jones· 1 shared E. M. Reynolds· 1 shared F. M. Mason· 1 shared G. C. Howard· 1 shared J. Wang· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. C. Florian

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1 paper

Recent·Most cited

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

G. C. Howard, J. Wang, K. L. Rose, C. Jones, P. Patel, T. Tsui, A. C. Florian, L. Vlach, S. L. Lorey, B. C. Grieb, B. N. Smith, M. J. Slota, E. M. Reynolds, S. Goswami, M. R. Savona, , W. P. Tansey

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

bioRxiv · Jul 26, 2023Cancer Biology