P. Patel

Peripheral Neuropathy After Chronic Alcohol Exposure in Mice: Impact of sex, total intake and duration and alcohol metabolism.

This study investigates the effects of chronic alcohol exposure on peripheral neuropathy in mice, identifying sex, intake duration, and acetaldehyde as key factors in neuroinflammation and hypersensitivity.

BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection

This study identifies BPP43_05035 as a Brachyspira pilosicoli adhesin that disrupts epithelial tight junctions, increasing barrier permeability during infection.

Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organelles

This study uses super-resolution microscopy to reveal the nanoscale organization of SARS-CoV-2 replication organelles, showing distinct vgRNA and dsRNA clusters and changes over infection stages.

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.

This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.

Salivary exosomal miR-1307-5p predicts disease aggressiveness and poor prognosis in oral squamous cell carcinoma patients

This study identifies miR-1307-5p in salivary exosomes as a prognostic marker for poor survival and disease aggressiveness in oral squamous cell carcinoma.

A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma

This study identifies a 3-miRNA signature in salivary exosomes that predicts OSCC progression and reveals its role in regulating EMT and tumor cell behavior.

CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer

Chlorpyrifos degradation by combined solar photo-Fenton and bacterial metabolism and simultaneous toxicity analysis in zebrafish (Danio rerio)

This study evaluates the combined solar photo-Fenton and bacterial degradation of chlorpyrifos in wastewater and assesses its toxicity to zebrafish.

Therapeutic role of Filarial HSP70 in murine models of polymicrobial sepsis and H1N1 Influenza

A filarial HSP70 protein acts as an adjuvant therapy, improving survival in murine polymicrobial sepsis and viral infection, with nasal administration protecting against H1N1 influenza.

Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response

This study uses single-cell RNA-sequencing to characterize human dura and meningioma, revealing distinct immune microenvironments and TCR overlap between matched samples.

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

This study identifies RNF168-mediated recruitment of the BRCA1-PALB2 complex to DNA damage through BARD1 and mUb-H2A.

The Evolutionary History of Small RNAs in the Solanaceae

The paper uses over 255 small RNA datasets to characterize the small RNA landscape across the Solanaceae family, revealing dynamic evolutionary patterns and genus-specific similarities.

miRador: a fast and precise tool for the prediction of plant miRNAs

miRador is a tool for plant miRNA prediction that is as precise as existing tools but significantly faster.

High resolution profiling of MHC-II peptide presentation capacity, by Mammalian Epitope Display, reveals SARS-CoV-2 targets for CD4 T cells and mechanisms of immune-escape

The paper uses a new platform to profile MHC-II peptide presentation capacity for SARS-CoV-2, revealing immune evasion mechanisms and CD4 T cell targets.

Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin

This study identifies SARS-CoV-2 nucleocapsid protein as a potent activator of human endothelial cells, showing that simvastatin inhibits this activation through TLR2/NF-κB and MAPK pathways.

Potential Early Rabies Infection Detected in Two Raccoon Cases by LN34 pan-lyssavirus real-time RT-PCR Assay in Pennsylvania

The paper identifies two early rabies infection cases in raccoons using LN34 RT-qPCR, showing higher viral levels in caudal brain regions and confirming low-level infections.

Modifying TIMER, a slow-folding DsRed derivative, for optimal use in quickly-dividing bacteria

The paper develops a modified TIMER variant (TIMER42) to identify slow-growing bacteria in host tissues, showing it accumulates signal in stationary phase and under nitric oxide stress.

The Flowering Time Regulator FLK Controls Pathogen Defense in Arabidopsis thaliana

This study identifies FLK as a regulator of pathogen defense in Arabidopsis, showing it affects resistance to bacterial and fungal pathogens through modulation of defense signaling and ROS scavenging.

Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganization

Suspended multiwalled, acid-functionalized carbon nanotubes promote aggregation of the opportunistic pathogen Pseudomonas aeruginosa

The paper investigates how low concentrations of multiwalled carbon nanotubes promote aggregation of Pseudomonas aeruginosa in aqueous systems, potentially increasing human exposure to bacterial aggregates.

The HIV-1 Vpu transmembrane domain topology and formation of a hydrophobic interface with BST-2 are critical for Vpu-mediated BST-2 downregulation

This study shows that the topology and hydrophobic interface of HIV-1 Vpu are critical for BST-2 downregulation, with shape and interface availability being more important than amino acid conservation.

Quantitative Mapping of Human Hair Graying and Reversal in Relation to Life Stress

This study quantifies hair graying and its reversal in humans, linking it to stress and showing proteomic and computational evidence of reversibility.

Reproductive phasiRNA loci and DICER-LIKE5, but not microRNA loci, diversified in monocotyledonous plants

The paper characterizes miRNA, siRNA, and phasiRNA diversity across 38 monocot species, finding 21-nt reproductive phasiRNAs are more common in grasses and DCL5 likely originated before grass diversification.

FYN tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates anti-glioma immune responses

This study shows that FYN tyrosine kinase in glioma cells suppresses anti-glioma immune responses, and its inhibition reduces tumor growth and improves survival in immune-competent models.

DAF-16 and SMK-1 contribute to innate immunity during adulthood in Caenorhabditis elegans

This study shows that DAF-16 and SMK-1 enhance innate immunity in adult C. elegans by compensating for the decline of PMK-1 pathway function with age.

Investigation on the effect of sonic stimulation on Xanthomonas campestris at the whole transcriptome level

This study examines how sonic stimulation affects Xanthomonas campestris at the transcriptome level, finding differential gene expression and increased exopolysaccharide production at 66 dB.

Prevention of enteric bacterial infections and modulation of gut microbiota composition with conjugated linoleic acids producing Lactobacillus in mice

This study shows that the probiotic Lactobacillus casei strain LC+mcra reduces Salmonella and EHEC infections in mice by modulating gut microbiota composition and improving gut health.

HSV-1 single cell analysis reveals anti-viral and developmental programs activation in distinct sub-populations

The paper uses single-cell analysis to show HSV-1 infection leads to distinct transcriptional programs in different cell sub-populations, including anti-viral responses and reprogramming to an embryonic-like state.

Investigating the influence of extraction methodology, and certain other experimental parameters on bacterial response to selected quorum-modulatory plant extracts

This study examines how extraction methods and experimental parameters affect bacterial response to plant extracts, finding that microwave- and vacuum-assisted methods yield stable anti-pathogenic efficacy.