Author

S. L. Lorey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

J. Wang· 2 shared Q. Liu· 2 shared A. C. Florian· 1 shared A. M. Weissmiller· 1 shared B. C. Grieb· 1 shared B. N. Smith· 1 shared C. Jones· 1 shared C. M. Adams· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

J. Wang

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2 papers

Recent·Most cited

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

G. C. Howard, J. Wang, K. L. Rose, C. Jones, P. Patel, T. Tsui, A. C. Florian, L. Vlach, S. L. Lorey, B. C. Grieb, B. N. Smith, M. J. Slota, E. M. Reynolds, S. Goswami, M. R. Savona, , W. P. Tansey

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

bioRxiv · Jul 26, 2023Cancer Biology

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1

T. M. Popay, J. Wang, C. M. Adams, S. G. Codreanu, S. D. Sherrod, J. A. McLean, L. R. Thomas, S. L. Lorey, Y. J. Machida, A. M. Weissmiller, C. M. Eischen, Q. Liu, W. Tansey

This study identifies HCF-1 as a critical co-factor for MYC in driving mitochondrial and ribosome biogenesis gene expression, and shows its impact on cell growth and tumor progression.

bioRxiv · Jun 22, 2020Cancer Biology