Author

B. N. Smith

King's College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. R. Savona· 2 shared A. C. Florian· 1 shared Adriano ChiòiD· 1 shared Ahmad Al KhleifatiD· 1 shared Alan Edward RentoniD· 1 shared Aleksey ShatunoviD· 1 shared Alfredo IacoangeliiD· 1 shared Ammar Al‐ChalabiiD· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

M. R. Savona

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

G. C. Howard, J. Wang, K. L. Rose, C. Jones, P. Patel, T. Tsui, A. C. Florian, L. Vlach, S. L. Lorey, B. C. Grieb, B. N. Smith, M. J. Slota, E. M. Reynolds, S. Goswami, M. R. Savona, , W. P. Tansey

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

bioRxiv · Jul 26, 2023Cancer Biology

In Situ Microwave Fixation to Define the Terminal Rodent Brain Metabolome

J. A. Juras, M. B. Webb, L. E. A. Young, K. H. Markussen, T. R. Hawkinson, M. D. Buoncristiani, K. E. Bolton, P. T. Coburn, M. I. Wiliams, L. P. Sun, W. C. Sanders, R. C. Bruntz, L. R. Conroy, C. Wang, M. S. Gentry, , R. C. Sun

This study uses microwave fixation to preserve brain metabolites in mice, showing reduced glucose metabolism in diabetic models and altered metabolic enzyme expression.

bioRxiv · Aug 16, 2022 · PreprintBiochemistry

Mutations in the SPTLC1 gene are a cause of juvenile amyotrophic lateral sclerosis that may be amenable to serine supplementation

Janel O. Johnson, Ruth Chia, Danny E. Miller, Rong Li, Yevgeniya A. Abramzon, Ravindran Kumaran, Nada F. Alahmady, Faraz Faghri, Alan Edward Renton, Simon D. Topp, Hannah A. Pliner, Jesse Raphael Gibbs, Jinhui Ding, N. Smith, Natalie Landeck, , Bryan J. Traynor

The paper identifies de-novo SPTLC1 mutations in juvenile ALS patients and suggests serine supplementation may alleviate symptoms.

bioRxiv · Jun 29, 2020 · PreprintGenetics

MCL1 dependence across MDS subtypes and dual inhibition of MCL1 and BCL2 in MISTRG6 mice

M. A. Fischer, Y. Song, R. Gbyli, M. P. Arrate, M. T. Villaume, M. A. Childress, B. N. Smith, T. P. Stricker, S. Halene, M. R. Savona

The paper assesses MCL1 dependence in MDS subtypes and shows that combined inhibition of BCL2 and MCL1 is synergistic in vitro and reduces MDS engraftment in mice.

bioRxiv · Jun 5, 2020 · PreprintCancer Biology