Author

K. L. Rose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

A. C. Florian· 1 shared A. Jones· 1 shared A. Reddy· 1 shared B. C. Grieb· 1 shared B. F. Eichman· 1 shared B. H. Greer· 1 shared B. N. Smith· 1 shared C. Jones· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. C. Florian

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Author profile →

3 papers

Recent·Most cited

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

G. C. Howard, J. Wang, K. L. Rose, C. Jones, P. Patel, T. Tsui, A. C. Florian, L. Vlach, S. L. Lorey, B. C. Grieb, B. N. Smith, M. J. Slota, E. M. Reynolds, S. Goswami, M. R. Savona, , W. P. Tansey

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

bioRxiv · Jul 26, 2023Cancer Biology

RTEL1 and MCM10 overcome topological stress during vertebrate replication termination

L. V. Campos, B. H. Greer, D. R. Heintzman, T. Kavlashvili, W. H. McDonald, K. L. Rose, B. F. Eichman, J. M. Dewar

The paper identifies RTEL1 and MCM10 as proteins that help replication forks overcome topological stress during DNA synthesis termination in Xenopus egg extracts.

bioRxiv · Jan 27, 2022Biochemistry

SETD2 regulates the methylation of translation elongation factor eEF1A1 in clear cell renal cell carcinoma

R. Hapke, L. Venton, K. L. Rose, Q. Sheng, A. Reddy, A. Jones, W. K. Rathmell, S. M. Haake

The paper investigates how SETD2 mutations in clear cell renal cell carcinoma affect protein methylation and translation, finding dysregulated translation linked to poor patient outcomes.

bioRxiv · Oct 26, 2020Cancer Biology