Tao Wang

Xenograft supervision and joint methylation-fragment-end encoding define a reusable molecular scoring layer for cell-free tumor DNA

ctDNA-BERT scores individual bisulfite reads for cell-free DNA methylation analysis, achieving high accuracy in cancer staging without cohort-specific retraining.

K9HeartCircDB: A circRNA Atlas of Tachypacing-Induced Canine Dilated Cardiomyopathy

The paper introduces K9HeartCircDB, a database of circRNAs in canine heart tissue under tachypacing-induced HF, providing tools for circRNA exploration and validation.

The glucocorticoid dexamethasone influences motility of the sulfate-reducing bacterium Desulfovibrio desulfuricans by targeting the filament cap protein FliD

This paper shows dexamethasone affects Desulfovibrio desulfuricans motility by binding to FliD, a flagellar cap protein, without relying on metabolism.

CK2 directly controls CARD9 protein homeostasis

This study identifies CK2 as a regulator of CARD9 protein stability, showing CK2 inhibition leads to CARD9 depletion and demonstrating therapeutic potential in vivo.

Dataset Documentation for Responsible AI: Analysis of Suitability and Usage for Health Datasets

This study evaluates five dataset documentation approaches for health datasets and finds none are widely used or fully suitable, recommending a new standard with guidelines and tools.

Modular organization and selective motifs in the insula provide structural priors for efficient learning

The paper maps the insular cortex's intra-architecture and shows it provides computational advantages for efficient learning in neural networks.

FAM134B isoform 2/RETREG1-2 defines a calnexin-TOLLIP-coupled ER-phagy pathway that restricts Ebola virus glycoprotein and is antagonized by VP40 through macro-autophagy

This paper identifies RETR1-2 as an ER-phagy receptor that restricts Ebola virus glycoprotein through a calnexin-TOLLIP pathway, which is counteracted by VP40 via macro-autophagy.

Folate Receptor α Contributes to Radiation Resistance in Neuroendocrine Prostate Cancer by Regulating Redox Homeostasis

This study identifies folate receptor α as a key contributor to radiation resistance in neuroendocrine prostate cancer by maintaining redox homeostasis through the folate-FR axis.

A Wearable Brain--Computer Interface for Mitigating Car Sickness via Attention Shifting

This paper introduces a wearable BCI system using AI to mitigate car sickness through attention shifting, showing over 83% effectiveness in reducing symptoms.

A Paracrine-to-Autocrine Shunt of GREM1 Fuels Colorectal Cancer Metastasis via ACVR1C

This study identifies a paracrine-to-autocrine GREM1 signaling shunt in colorectal cancer that promotes metastasis via ACVR1C, highlighting a mechanism of signaling autonomy in advanced stages.

A NEW DYSTROPHIN DEFICIENT RAT MODEL MIRRORING EXON SKIPPING IN PATIENTS WITH DMD EXON 45 DELETIONS

This paper describes a novel rat model with an exon 45 deletion in the Dmd gene, showing features of DMD and exon skipping, which may inform personalized therapies.

Fat-rich diet reprograms intrapulmonary neutrophils to boost tissue-specific antitumor immunity

This study shows that fat-rich diets enhance antitumor immunity in the lungs by reprogramming intrapulmonary neutrophils through vascular endothelial cell interactions.

Patient-Derived Xenograft-Guided Prediction of Chemotherapy Response in Triple-Negative Breast Cancer

This paper develops chemotherapy-specific predictors for triple-negative breast cancer using patient-derived xenografts and multi-omic data, achieving high AUROC scores for response prediction.

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

Low-dose chemotherapy combined with delayed immunotherapy in the neoadjuvant treatment of non-small cell lung cancer and dynamic monitoring of the drug response in peripheral blood

This study evaluates a modified neoadjuvant chemo-immunotherapy regimen for NSCLC, showing improved response rates and reduced side effects with dynamic monitoring of ctDNA and TCR.

The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2

The paper predicts T cell and B cell immunogenic epitopes of SARS-CoV-2 using genomic data and compares them with SARS-CoV and MERS-CoV to identify immune vulnerability patterns.