Thomas S. Webb

No evidence for direct physical interaction of 5-HT2A-mGluR2 receptors in vitro or in vivo

The paper investigates whether mGluR2 and 5-HT2A receptors physically interact in vitro or in vivo and finds no evidence for direct interaction or oligomerization.

Sequential Penta-Omic Extraction Method Using Single Biospecimens of Post-mortem Human Brain

The paper describes a penta-omic sequential extraction method for post-mortem human brain samples, showing minimal omic loss and preserved tissue integrity compared to single-omic methods.

The RING Finger E3 Ligase RNF25 Protects DNA Replication Forks Independently of its Canonical Roles in Ubiquitin Signaling

This study identifies RNF25's role in protecting DNA replication forks from degradation, independent of its ubiquitin signaling functions.

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice.

This study examines temporal changes in extracellular vesicle (EV) protein cargo in burn-injury patients and mice, showing distinct immune reprogramming effects at early and late post-injury stages.

Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells

The paper identifies UNC10013, a covalent ligand targeting SETDB1's 3TD domain, which reduces methyltransferase activity and shows selectivity in cells.