Author

C. Walkey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. J. Borst· 2 shared B. Fiala· 2 shared D. Baker· 2 shared D. Veesler· 2 shared J. Y. Wang· 2 shared N. P. King· 2 shared Y. Hsia· 2 shared A. Antanasijevic· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

A. J. Borst

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Hierarchical design of pseudosymmetric protein nanoparticles

Q. Dowling, Y.-J. Park, N. Gerstenmaier, E. Yang, A. Wargacki, Y. Hsia, C. Fries, R. Ravichandran, C. Walkey, A. Burrell, D. Veesler, D. Baker, N. King

The paper designs large pseudosymmetric protein nanoparticles using a hierarchical computational method, achieving sizes up to 96 nm with 960 subunits.

bioRxiv · Jun 16, 2023 · PreprintBioengineering

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

J. Y. Wang, A. Khmelinskaia, W. Sheffler, M. C. Miranda, A. Antanasijevic, A. J. Borst, S. V. Torres, C. Shu, Y. Hsia, U. Nattermann, D. Ellis, C. Walkey, M. Ahlrichs, S. Chan, A. Kang, , N. P. King

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

bioRxiv · Aug 4, 2022Biochemistry

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

H. Malhi, L. J. Homad, Y.-H. Wan, B. Poudel, B. Fiala, A. J. Borst, J. Y. Wang, C. Walkey, J. Price, A. Wall, S. Singh, Z. Moodie, S. Handa, C. Correnti, B. L. Stoddard, , A. McGuire

This study evaluates a nanoparticle vaccine displaying EBV gH/gL, showing it protects humanized mice against lethal EBV challenge, while monomeric gH/gL does not.

bioRxiv · Feb 17, 2022Immunology