Author

C. Shu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Bioengineering· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:host-pathogen & immune response· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Wahafu· 2 shared D. Cicka· 2 shared D. Fan· 2 shared H. Fu· 2 shared Q. Niu· 2 shared S. Doyle· 2 shared T. Owonikoko· 2 shared W. Zhou· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Wahafu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single-nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root

X. Liu, Q. Zeng, H. Yang, W. Li, Q. Chen, K. Yin, Z. Pan, K. Wang, M. Luo, C. Shu, Z. Zhou

This study uses single-nucleus multiomic and spatial transcriptomic data to identify gene regulatory dynamics and key regulators in human aortic root tissue under healthy and Marfan syndrome conditions.

bioRxiv · Feb 27, 2024Pathology

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

J. Y. Wang, A. Khmelinskaia, W. Sheffler, M. C. Miranda, A. Antanasijevic, A. J. Borst, S. V. Torres, C. Shu, Y. Hsia, U. Nattermann, D. Ellis, C. Walkey, M. Ahlrichs, S. Chan, A. Kang, , N. P. King

This study identifies cryptic transmembrane domains in designed protein nanoparticles that hinder secretion and introduces a computational tool, Degreaser, to remove them while maintaining stability, improving secretion efficiency.

bioRxiv · Aug 4, 2022Biochemistry

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice

R. Sun, Z. Zhao, C. Fu, Y. Wang, Z. Guo, C. Zhang, L. Liu, C. Zhang, C. Shu, J. He, S. Hua, Y. Gao, Z. Hu

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

bioRxiv · Nov 5, 2021 · PreprintImmunology

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

X. Mo, Q. Niu, A. A. Ivanov, Y. H. Tsang, C. Tang, C. Shu, A. Wahafu, S. Doyle, D. Cicka, X. Yang, D. Fan, M. A. Reyna, L. A. D. Cooper, C. S. Moreno, W. Zhou, , H. Fu

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.

bioRxiv · Oct 3, 2021Cancer Biology

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

C. Shu, R. Jin, Q. Niu, D. Cicka, S. Doyle, A. Wahafu, D. Fan, X. Zheng, Y. Du, A. Ivanov, D. Doxie, K. Dhodapkar, J. Carlisle, T. Owonikoko, S. Ramalingam, , H. Fu

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Reconciling Inherent Interfacial Compatibility Conflict Enhances Adhesive Infiltration and Resolves Dentin Bonding Durability

Q. Luo, Y. Chen, J. Xu, C. Shu, Z. Li, W. Zhu, Y. Shen, X. Li

This paper identifies interfacial compatibility conflict as the cause of poor dentin bonding durability and shows that hydrophobizing the demineralized dentin matrix enhances adhesive infiltration and bonding strength.

bioRxiv · Feb 9, 2021 · PreprintBioengineering