ImmunologybioRxivPreprint
A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling
A. Vasou, K. Nightingale, V. Cetkovska…·D. J. Hughes
The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.
DOI 10.1101/2021.06.01.446527