Author

K. Nightingale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. J. Davison· 3 shared J. Nichols· 3 shared L. Nobre· 3 shared M. P. Weekes· 3 shared R. J. Stanton· 3 shared C. A. Fielding· 2 shared E. C. Y. Wang· 2 shared M. Potts· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMicrobiology

A. J. Davison

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

A. Rubina, M. Patel, K. Nightingale, M. Potts, C. A. Fielding, S. Kollnberger, B. Lau, K. Ladell, K. L. Miners, J. Nichols, L. Nobre, D. Roberts, T. M. Trinca, J. P. Twohig, V.-M. Vlahava, , E. C. Y. Wang

This paper identifies how HCMV targets ADAM17 to modulate surface proteins and immune pathways, revealing a novel viral immunomodulation strategy.

bioRxiv · Mar 16, 2023Microbiology

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling

A. Vasou, K. Nightingale, V. Cetkovska, J. Scheler, C. G. Bamford, J. Andrejeva, U. Schwarz-Linek, R. E. Randall, J. McLauchlan, M. P. Weekes, D. Bogunovic, D. J. Hughes

The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.

bioRxiv · Jun 1, 2021 · PreprintImmunology

Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex

K. Nightingale, C. A. Fielding, C. Zerbe, L. Hunter, M. Potts, A. Fletcher-Etheringon, L. Nobre, E. C. Y. Wang, B. L. Strang, J. Houghton, R. Antrobus, N. M. Suarez, J. Nichols, A. J. Davison, R. J. Stanton, M. P. Weekes

This study identifies HCMV protein RL1 as a viral antagonist that degrades SLFN11 via CRL4 E3 ubiquitin ligase, revealing SLFN11's role in restricting HCMV infection.

bioRxiv · May 14, 2021Microbiology

Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor

A. Fletcher-Etherington, L. Nobre, K. Nightingale, R. J. Antrobus, J. Nichols, A. J. Davison, R. J. Stanton, M. P. Weekes

This paper identifies HCMV protein pUL36 as a dual inhibitor of apoptotic and necroptotic cell death by degrading MLKL and preventing caspase 8 activation.

bioRxiv · Feb 3, 2020Microbiology