Author

V. Bigley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

M. Collin· 4 shared A. Publicover· 2 shared M. Haniffa· 2 shared P. Milne· 2 shared S. Pagan· 2 shared A. Burnett· 1 shared A. Dickinson· 1 shared A. Elder· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCancer Biology

M. Collin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

R. Tirtakusuma, K. Szoltysek, P. Milne, V. V. Grinev, A. Ptasinska, C. Meyer, S. Nakjang, J. Y. Hehir-Kwa, D. Williamson, P. Cauchy, S. A. Assi, M. R. Imperato, F. Vogiatzi, S. Lin, M. Wunderlich, , M. J Thirman

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

bioRxiv · Jul 16, 2021Cancer Biology

Donor monocyte-derived macrophages promote human acute graft versus host disease

L. Jardine, U. Cytlak, M. Gunawan, G. Reynolds, K. Green, X.-N. Wang, S. Pagan, M. Pradnya, C. A. Lamb, A. K. Long, E. Hurst, S. Nair, G. Jackson, A. Publicover, V. Bigley, , M. Collin

The paper identifies donor monocyte-derived macrophages as key players in human acute graft versus host disease, showing their enhanced activation of T cells and secretion of inflammatory cytokines.

bioRxiv · Sep 30, 2019Immunology

A rule-based data-informed cellular consensus map of the human mononuclear phagocyte cell space

P. Guenther, B. Cirovic, K. Bassler, K. Haendler, M. Becker, C. A. Dutertre, V. Bigley, E. W. Newell, M. Collin, F. Ginhoux, A. Schlitzer, J. L. Schultze

The paper develops a rule-based data-informed approach to create a consensus map of the human mononuclear phagocyte cell space using computational integration and single-cell RNA-sequencing.

bioRxiv · Jun 3, 2019 · PreprintImmunology

Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia

P. Milne, C. Wilhelm-Benartzi, M. R. Grunwald, V. Bigley, A. Publicover, S. Pagan, H. Marr, G. Jones, A. Dickinson, A. Grech, A. Burnett, N. Russell, M. Levis, S. Knapper, M. Collin

This paper shows that serum Flt3L levels correlate with progenitor cell mass and prognosis in AML, with lower levels linked to worse outcomes and relapse.

bioRxiv · Mar 25, 2019Cancer Biology