Author

V. De Simone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:clustering· 1

Frequent Co-Authors

G. Matteoli· 4 shared L. van Baarle· 3 shared M. Stakenborg· 3 shared S. Abdurahiman· 3 shared B.-J. Ke· 2 shared F. Biscu· 2 shared S. Ibiza· 2 shared S. Santhosh· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersImmunology

G. Matteoli

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

L. van Baarle, V. De Simone, L. Schneider, S. Santhosh, S. Abdurahiman, F. Biscu, R. Schneider, L. Zanoletti, S. Verbandt, Z. Hu, M. Stakenborg, B.-J. Ke, B. Garcia-Reyes, J. Henn, M. Toma, , G. Matteoli

This study identifies IL-1R signaling as a driver of enteric glia-macrophage interactions in colorectal cancer, promoting tumor progression through IL-6 secretion.

bioRxiv · Jun 1, 2023Cancer Biology

Intercellular interaction between FAP fibroblasts and CD150 inflammatory monocytes mediates fibro-stenosis in Crohn's disease

B.-J. Ke, S. Abdurahiman, F. Biscu, G. Dragoni, S. Santhosh, V. De Simone, A. Zouzaf, L. van Baarle, M. Stakenborg, V. Bosakova, Y. Van Rymenant, E. Verhulst, S. Verstockt, G. Bislenghi, A. Wolthuis, , G. Matteoli

The paper identifies intercellular interactions between FAP fibroblasts and CD150 monocytes that drive fibro-stenosis in Crohn's disease and shows TWIST1 inhibition can reduce fibrosis.

bioRxiv · May 4, 2023Immunology

Enteric glial cells favour accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

M. Stakenborg, S. Abdurahiman, V. De Simone, G. Goverse, N. Stakenborg, L. Van Baarle, Q. Wu, D. Pirottin, J.-S. Kim, L. Maor, I. Pintelon, S. Thys, L. Boon, M. Hao, J. Van Ginderachter, , G. Matteoli

This study identifies how enteric glial cells promote the differentiation of anti-inflammatory macrophages during muscularis inflammation resolution through CCL2 and CSF1 signaling.

Mucosal Immunology · Nov 1, 2022Peer-reviewedImmunology

Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4+ T cells

M. Lancien, G. Bienvenu, L. Gueno, S. Salle, E. Merieau, S. Remy, A. Even, A. Moreau, A. Molle, C. Fourgeux, F. Coulon, G. Beriou, L. Bouchet-Delbos, E. Chiffoleau, P. Kirstetter, , C. Louvet

The paper shows TMEM176A/B ion channels are essential for dendritic cells to present antigens to CD4+ T cells, but not for Th17 or ILC3 function.

bioRxiv · May 1, 2020 · PreprintImmunology